The following information is about Circulation.

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Off-site Circulation Links, User Submitted

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Thu Jul 2

• Transports Qubec : Qubec 511 - tat du rseau routier: Toute l'informa tion sur les chantiers routiers.
• Read Aloud Night at Gerber/Hart Library
• Web Management Reports: site for circ. statistics
• Impaired Impulse Propagation in Scn5a-Knockout Mice: Combined Contribution of Excitability, Connexin Expression, and Tissue Architecture in Relation to Aging -- van Veen et al. 112 (13): 1927 -- Circulation: A 50% reduction in Scn5a expression alone or age-related interstitial fibrosis only slightly affects conduction. In aged HZ mice, reduced Scn5a expression is accompanied by the presence of reactive fibrosis and disarrangement of gap junctions, which results in profound conduction impairment.
• Slow Conduction and Enhanced Anisotropy Increase the Propensity for Ventricular Tachyarrhythmi as in Adult Mice With Induced Deletion of Connexin43 -- van Rijen et al. 109 (8): 1048 -- Circulation: Heterozygous expression of Cx43 did not affect ventricular conduction velocity. Up to 95% decrease of Cx43 protein in 4-OHT?treated Cx43Cre-ER(T)/ fl mice reduced conduction velocity and increased dispersion of conduction and propensity for ventricular arrhythmias.
• Ionic Mechanism of Action Potential Prolongation in Ventricular Myocytes From Dogs With Pacing-Induced Heart Failure -- Kääb et al. 78 (2): 262 -- Circulation Research: Membrane current abnormalities have been described in human heart failure. To determine whether similar current changes are observed in a large animal model of heart failure, we studied dogs with pacing-induced cardiomyopathy .
• Remodeling in Cells From Different Regions of the Reentrant Circuit During Ventricular Tachycardia -- Baba et al. 112 (16): 2386 -- Circulation: We mapped reentrant circuits in the EBZ of infarcted hearts during sustained ventricular tachycardias (>30 seconds, n=17 episodes, cycle lengths=218±7. 9 ms). INa density was reduced in both IZc and IZo, and the kinetic properties of IZc INa were markedly altered versus IZo. Structural remodeling of the sodium channel protein Nav1.5 occurred in IZs, with cell surface localization differing from normal cells. Both IZc and IZo have similar but reduced ICaL, whereas IZc showed changes in Ca2+ current kinetics with an acceleration of current decay. Computer simulations of the 2D EBZ showed that incorporating only differences between INa in IZc and IZo prevented stability of the reentrant circuit. Incorporating only differences between ICaL in the IZc and IZo cells also prevented stability of the circuit. However, incorporating both INa and ICaL current differences stabilized the simulated reentrant circuit, and lines of block formed between the 2 distinct regions.
• Molecular Basis of Arrhythmias -- Shah et al. 112 (16): 2517 -- Circulation: The characterizati on of single gene disorders has provided important insights into the molecular pathogenesis of cardiac arrhythmias. Primary electricalal diseases including long-QT syndrome, short-QT syndrome, Brugada syndrome, and catecholaminer gic polymorphic ventricular tachycardia have been associated with mutations in a variety of ion channel subunit genes that promote arrhythmogenes is. Pathological remodeling of ionic currents and network properties of the heart critical for normal electrical propagation plays a critical role in the initiation and maintenance of acquired arrhythmias. This review focuses on the molecular and cellular basis of electrical activity in the heart under normal and pathophysiolog ical conditions to provide insights into the fundamental mechanisms of inherited and acquired cardiac arrhythmias. Improved understanding of the basic biology of cardiac arrhythmias holds the promise of identifying new molecular targets for the treatment of cardiac arrhythmias.

Wed Jul 1

• Stiggly Holistics NYC: Hot Towel Scrub
• Laptop City Hall: Laptop City Hall: Are libraries losing their ...: Madison libraries circulation

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Off-site Circulation Research Links

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