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Thiazolidinediones Defined

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Off-site Thiazolidinediones Links, User Submitted

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Tue Jun 23

• Heart study questions diabetes drugs : Nature News | A molecular pathway could explain how a class of drugs leads to heart failure.: A class of diabetes drugs including Avandia is known to raise the risk of heart failure. Researchers who study how tumours balloon in size have discovered one way that enlargement of the heart can lead to heart failure. The work, although mostly done in mice, could help explain why a class of diabetes drugs called thiazolidinedi ones (TZDs) increase the risk of heart failure. A 2007 analysis of Avandia (rosiglitazone ), a TZD made by GlaxoSmithKlin e, suggested that patients taking it are at increased risk of heart attack. Less controversial are data linking TZDs with heart failure, a distinct condition in which the heart cannot pump enough blood through the body. "We already knew if you had heart failure you probably should not be taking these drugs, but this paper provides an additional explanation why," says Clay Semenkovich, an endocrinologis t. The work suggests that a molecule activated by TZDs, called PPAR-?, underlies one aspect of heart failure.

Wed Apr 8

• Diabetes medication pills information: Alpha-Glucosid ase Inhibitor, Biguanide, D-Phenylalanin e derivative, DPP-4 Inhibitor, Meglitinide, Sulfonylurea, Thiazolidinedi one & its side effects.

Tue Jan 13

• Popular Class Of Diabetes Drugs Doubles Risk Of Fractures In Women

Fri Nov 16

• FDA Adds Heart Attack Warning to Rosiglitazone

Wed Oct 3

• Thiazolidinedi ones: effects on insulin resistance and the cardiovascular system ____FREE PDF: C E Quinn, P K Hamilton, C J Lockhart and G E McVeigh. Br J Pharmacol advance online publication, October 1, 2007; doi:10.1038/sj .bjp.0707452

Sat Jul 14

• Lab disaster may lead to new cancer drug - Cancer - MSNBC.com: So you're telling me that thiazolidinedi ones (rosiglitazone , pioglitazone, etc.) can cure colon cancer? This should be easy to study: find all your diabetics and see if they have a lower rate of colon cancer than the general population. GSK? Takeda Pharma

Mon Dec 4

• 2-deoxyglucose ketogenic diet PEPCK and epilepsy

Tue Nov 28

• Glyceroneogene sis and fatty acid cycling

Sat Feb 5

• Penn Study Shows How Next-generatio n Diabetic Drugs Could Work More Selectively

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